Use of opioid analgesics for an extended time frame for the duration of pregnancy may possibly induce neonatal opioid withdrawal syndrome [see WARNINGS AND Safeguards]. There won't be any offered knowledge with DILAUDID INJECTION in pregnant Women of all ages to inform a drug-connected danger for key beginning defects and miscarriage or adverse maternal outcomes.
The subsequent significant adverse reactions are explained, or explained in larger depth, in other sections:
Drink Alcoholic beverages or use prescription or around-the-counter medicines that consist of Liquor. Applying merchandise containing Liquor in the course of treatment method with DILAUDID Tablets or DILAUDID Oral Solution could bring about you to definitely overdose and die.
The pharmacokinetics of hydromorphone in people with extreme hepatic impairment has not been researched. A further increase in Cmax and AUC of hydromorphone With this group is predicted and should be taken into consideration when deciding upon a starting up dose [see Use in Distinct Populations (8.6)].
DILAUDID INJECTION has sodium metabisulfite, a sulfite which will cause allergic-style reactions like anaphylactic indicators and lifestyle-threatening or fewer significant asthmatic episodes in selected susceptible men and women.
The concomitant use of opioids with other medicines that influence the serotonergic neurotransmitter procedure has resulted in serotonin syndrome
Elderly people (aged 65 yrs or older) could have increased sensitivity to hydromorphone. On the whole, use caution when picking out a dosage for an elderly patient, usually starting off with the read more reduced close in the dosing range, reflecting the increased frequency of lessened hepatic, renal, or cardiac functionality and of concomitant disease or other drug therapy.
DILAUDID INJECTION exposes people and various consumers to the challenges of opioid dependancy, abuse, and misuse, which may result in overdose and Demise.
This document isn't going to contain all doable Unwanted effects and Other people may perhaps manifest. Test using your doctor For added specifics of Uncomfortable side effects.
Labor or Shipping Opioids cross the placenta and may develop respiratory depression and psycho-physiologic consequences in neonates. An opioid antagonist, which include naloxone, must be available for reversal of opioid-induced respiratory melancholy inside the neonate. DILAUDID INJECTION just isn't suggested to be used in pregnant Women of all ages during or straight away previous to labor, when other analgesic strategies tend to be more acceptable.
Monitor people for indications of urinary retention or minimized gastric motility when DILAUDID INJECTION is made use of concomitantly with anticholinergic medicines.
Each and every drug may well produce other drug interactions which will boost your threat for really serious Unwanted side effects. You should definitely explain to your Health care supplier about all prescription drugs and in excess of-the-counter items that you’re having.
Hydromorphone injection may possibly lead to other Uncomfortable side effects. Simply call your medical professional In case you have any uncommon problems when you are utilizing this medication.
In a person physically dependent on opioids, administration on the advised regular dosage of the antagonist will precipitate an acute withdrawal syndrome. The severity of the withdrawal indications knowledgeable will depend upon the diploma of Actual physical dependence and the dose on the antagonist administered.